Epigenetics At The Epicenter Of Oncology Drug Discovery At AACR
This article was originally published in The Pink Sheet Daily
Epigenetics, an area of biology replete with interesting novel targets and potential for developing drugs that overcome cancer resistance, is a popular topic this year at the American Association for Cancer Research annual meeting, in Washington, D.C., April 6-10.
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Positive Phase III findings support Novartis’ plan for filing the pan-DAC inhibitor in 2014. The firm’s initial BLA for the compound, seeking accelerated approval in Hodgkin’s lymphoma, was rejected by FDA in 2011.
“Using our drugs, we’re trying to facilitate the old drugs or help them work better longer,” Astex’s Lyons said. Astex, AstraZeneca and Novartis all presented data on compounds from Astex’s fragment-based drug discovery platform at the recent American Association for Cancer Research meeting in Washington, D.C.