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Bydureon Approval Provides Lesson In Clinical Data Requirements For Biosimilars

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Changes in the manufacturing site and production scale for exenatide extended-release complicated FDA’s review of Bydureon, Amylin’s follow-on agent to Byetta, and late-rising questions about the drug’s QT effects made FDA revisit its earlier conclusion that the investigational and commercial formulations were comparable. The agency’s decision to require additional clinical data in a second “complete response” letter suggests biosimilar sponsors will face a similarly high clinical hurdle.

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