Pain Drug Development Becomes Personalized
This article was originally published in RPM Report
Advances in pain neurobiology point to the promise of more specific drugs with fewer side effects, yet the field continues to show few successes. Nevertheless, fast-advancing knowledge, a huge market, and better clinical study de-risking strategies should eventually overcome investor shyness about backing emerging personalized pain drug developers.
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Adynxx Inc.’s first clinical candidate is a one-time treatment to keep acute postoperative pain out of the brain. The same pain pathway-blocking strategy underlies a therapeutic pipeline the company plans to develop for the huge need for a better solution for the five million patients in the US who are treated for chronic pain annually.
Katama Pharmaceuticals Inc. was built around tolperisone, a generic, oral small molecule muscle relaxant manufactured and sold in Europe for the treatment of muscular pain and neuromuscular spasms. Katama aims to launch its version in the US, initially for treating acute lower back pain.