Oncologists Audition Yervoy And Zelboraf For First-line Roles, With New Combos In Near Sight
Cooperative group plans trial testing Yervoy vs. Zelboraf in first-line metastatic melanoma to help settle the issue of which therapy should come first in BRAF-mutation positive patients. New therapies on the way promise to further complicate decision-making.
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FDA approval for Opdivo and Yervoy in combination and Opdivo as monotherapy for the treatment of all metastatic melanoma patients, regardless of BRAF mutation status, puts Bristol on equal footing with Merck in the indication, and positions it to take on the BRAF inhibitors.
Approval for first-line BRAF+ patients puts Merck's Keytruda ahead of Bristol's Opdivo in melanoma, and in line to take share from BRAF/MEK combos, which are currently dominant in this patient population. Interactive timeline gives visual overview of immunotherapy approvals in key markets.
Phase I data for immune checkpoint molecules in melanoma from Bristol, Roche and Merck were a major highlight of the ASCO 2013 annual meeting. Considering potential application in many cancers regardless of genetic mutations, some analysts are predicting billions in future sales.