Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

7TM Pharma

This article was originally published in Start Up

Executive Summary

7TM Pharma aims to apply proprietary functional and structural knowledge of 7TM receptors to aid in the design of small-molecule therapeutics, and hopes to succeed commercially by choosing a specific therapeutic area-metabolic diseases, and in particular, obesity-on which to apply its technology.

You may also be interested in...



Norak Biosciences Inc.

Norak's founders think that beta-arrestin's movement from within the body of the cell to the membrane-bound receptor is a specific marker of GPCR receptor activation-and their method for watching it all happen in glowing green is the basis of the company's Transfluor technology.

Axovan Ltd.

Using proprietary high-throughput screening techniques, Axovan is now identifying compounds that bind to GPCRs with high affinity. It reduces screening time by taking into account the homology between receptors, which enables it to screen up to eight receptors in parallel: the company claims to be the only one able to screen up to 30 GPCR receptors per year.

Aptus Genomics Inc.

Researchers haven't yet been able to overcome the challenge of isolating and purifying GPCRs from their membrane in a functionally useful form, so it has been difficult to determine their structures, as a starting point for drug discovery. Researchers have, however, developed indirect ways of detecting whether particular compounds activate GPCRs, by measuring the effects of activation. The presence of certain secondary messengers within the cell, for example, calcium or cyclic AMP (cAMP), is a telltale sign that compounds have interacted with GPCRs. Aptus Genomics has applied for a patent for a high-throughput drug screening method for GPCRs that signal through cAMP.

Related Content

Topics

Related Companies

UsernamePublicRestriction

Register

SC090554

Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel