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Shire’s Motegrity: US FDA Panel Nod On CV Safety Comes With Concern About Neuropsych Events

Executive Summary

In unanimously endorsing prucalopride for chronic idiopathic constipation, advisory committee seems reassured by extensive data on 5-HT4 agonist’s cardiovascular safety, but some members called for an epidemiological study to assess possible suicidality signal.

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