Acetaminophen vs. ibuprofen
This article was originally published in The Tan Sheet
Executive Summary
Single doses of ibuprofen (4-10 mg/kg) and acetaminophen (7-15 mg/kg) have similar efficacy in treating moderate to severe pain in children under 18 years of age and similar safety as analgesics or antipyretics, study published in the June Archives of Pediatrics & Adolescent Medicine finds. However, ibuprofen (5-10 mg/kg) reduced temperature more effectively than acetaminophen (10-15 mg/kg) at 2, 4 and 6 hours after treatment, the researchers report. David Perrott, PhD, Sydney Children's Hospital, New South Wales, et al., examined 17 blind, randomized controlled trials with children receiving either single-dose acetaminophen or ibuprofen for the treatment of fever or moderate to severe pain...