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Soy genistein in mice

This article was originally published in The Tan Sheet

Executive Summary

"Use of soy formula for infant nutrition and high soy/isoflavone intake by adults through the use of supplements needs to be approached with caution," according to study appearing in May 28 Proceedings of the National Academy of Sciences. Srikanth Yellayi, et al., University of Illinois-Urbana, injected mice with genistein in doses ranging from 2-200 mg/kg per day and found the soy isoflavone produced dose-responsive reductions in thymic weight and size of up to 78% compared with control groups. Genistein also was found to impair humoral immunity and could inhibit immune function, researchers note. Yellayi et al. conclude "large-scale studies addressing immune function or morbidity in soy fed infants are needed to conclusively determine" if there are abnormalities associated with soy formula consumption...
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