Invirase, Fortovase To Strengthen Rifampin Drug Interaction Warning
This article was originally published in The Pink Sheet Daily
Executive Summary
Combination use was already contraindicated, but Roche conducted a study to see if boosting saquinavir with ritonavir would overcome the interaction. A Phase I study found significant hepatocellular toxicity, a "Dear Doctor" letter notes, but liver function in all affected subjects is returning to normal.