Revised Accutane Label Describes Lack Of PK Effect On Ortho-Novum
This article was originally published in The Pink Sheet Daily
Executive Summary
A study of 31 women showed Accutane at the recommended dose did not induce clinically relevant changes in the pharmacokinetics of the oral contraceptive. Accutane's "black box" warning concerning possible interactions between isotretinoin and oral contraceptives remains in labeling.