Comparative Effectiveness News In Brief

AHRQ updating CER report on off-label atypical antipsychotic use: The Agency for Healthcare Research and Quality is performing a routine update to its Jan. 17, 2007, comparative effectiveness 1review of the off-label use of atypical antipsychotics. The agency, in a comment request on its 2Web site, notes that since the original report was published, "some important changes have occurred and part of the conclusions of the original report might be out of date." Among the changes highlighted are the availability of new studies, including randomized control trials, that have provided more efficacy evidence on off-label use of atypicals; new off-label uses have been identified; previous off-label uses have become approved uses; and new or increased adverse effects of off-label indications have been observed. Comments are being accepted until Feb. 9