Aventis Amaryl

Geriatric use information added to precautions section of labeling for the blood-glucose lowering agent glimepiride. The subsection, approved Sept. 27, reports no differences in safety or effectiveness between patients over 65 and those under 65, but caution is advised in dose selection as "the risk of toxic reactions to this drug may be greater in patients with impaired renal function," which is more common in elderly patients. Renal monitoring is suggested, along with blood glucose monitoring