Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

VERTEX ORAL AIDS DRUGS PROGRAM WILL RECEIVE UP TO $20 MIL. FROM KISSEI

Executive Summary

VERTEX ORAL AIDS DRUGS PROGRAM WILL RECEIVE UP TO $20 MIL. FROM KISSEI for compounds targeting the HIV protease enzyme, Cambridge, Mass.-based Vertex Pharmaceuticals announced April 13. Under the agreement, the Japanese firm Kissei Pharmaceutical Co. Ltd. will provide Vertex with technical assistance and up to $20 mil. over three years in milestone payments, funding and a small equity investment toward the development of orally active HIV protease inhibitors. In exchange, Kissei gains the right to commercialize any HIV protease inhibitors that are developed through the collaboration in Japan and China. Kissei, which markets primarily cardiovascular and allergy drugs and had estimated sales of $350 mil. in FY 1993 (ended March 31), will pay Vertex royalties on those sales. Vertex retains marketing rights to the products in the rest of the world, as well as worldwide manufacturing rights for the bulk compounds. The rational drug design firm has several non-peptidal HIV protease inhibitor candidates in preclinical trials and could file an IND for a compound as early as the beginning of 1994. Vertex Senior Scientist Manuel Navia, PhD, was the first to report the molecular structure of the HIV protease enzyme while he worked at Merck. Vertex further explored the protease structure through X-ray crystallography experiments aboard the space shuttle Columbia last June ("The Pink Sheet" June 29, 1992, T&G-6). In October 1990, Vertex signed an R&D agreement with another Japanese firm, Chugai Pharmaceuticals, to fund its "Immunophilins" program. Under that agreement, Chugai through September has provided Vertex with $10 mil. and is slated to pay the firm $19 mil. in research funding and $9 mil. in milestone payments over five years. Initially, the research targeted the development of immunosuppressive drugs with less toxicity and more efficacy than cyclosporine and Fujisawa's experimental drug FK-506. The company has shifted its strategy so that multi-drug resistance in cancer therapy will be the first area of development for the Immunophilins.

You may also be interested in...



Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth

UsernamePublicRestriction

Register

LL1133951

Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel