Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By



Executive Summary

AEROSOLIZED PENTAMIDINE PROLONGS SURVIVAL BETTER THAN TMP/SMX in cases of advanced HIV disease, according to the results of a two-year, multicenter study of 1,048 AIDS patients. The study employed Fujisawa/Lyphomed's aerosolized pentamidine product Nebupent and the generically-available trimethoprim/sulfamethoxazole (marketed by Roche as Bactrim and by Burroughs Wellcome as Septra). Richard Chaisson, Johns Hopkins University School of Medicine, reported results of the study at the seventh International AIDS Conference in Florence, Italy, June 16-21. While both aerosolized pentamidine and TMP/SMX were associated with a decreased risk of development of Pneumocystis carinii pneumonia, only PCP prophylaxis with Nebupent was related to improved survival. Seventeen percent of patients who received TMP/SMX developed PCP, while 22% of patients given aerosolized pentamidine developed PCP. TMP/SMX is the drug of choice for many physicians because it has been considered to be equally efficacious and is a fraction of the cost of pentamidine. Chaisson's study is one of the first to compare the two drugs' effect on survival. Patients who remained on AZT more than 80% of the time also had prolonged survival, Chaisson said: "Aerosolized pentamidine therapy and zidovudine [AZT] therapy were each independently associated with improved survival." Of the 1,048 patients in the study, 60% received aerosolized pentamidine and 19% received TMP/SMX. Chaisson said many patients had low blood cell counts and may not have been able to tolerate TMP/SMX. But he noted that the adverse effects of TMP/SMX "may limit its long-term use."

You may also be interested in...

Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth




Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts