Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By



Executive Summary

Transgene's production systems for gamma interferon and interleukin-2 are being utilized by Roussel-Uclaf and Roussel-Uclaf/Sanofi, according to company information presented at a health care investment conference sponsored by L. F. Rothschild Oct. 21-22 in London. The French genetic engineering firm reported in background material that it has "developed sytems for producing gamma interferon under contract with Roussel-Uclaf, which is undertaking the product's pharmaceutical development." In addition, the joint venture firm Roussel-Uclaf/Sanofi has purchased Transgene's system for producing interleukin-2. Transgene President Etienne Eisenmann described the company's research efforts at the conference, which focused on European health care concerns. He indicated that at least one of Transgene's products, alpha-1-antitrypsin, is close to licensing, and said discussions are underway with a number of companies. Transgene explained that alpha-1-antitrypsin is naturally produced by the liver and when it is lacking, "either for hereditary reasons or due to smoking, emphysema occurs in the lungs." The company said it has produced the product in several microorganisms and using protein engineering techniques has also "designed and produced modified proteins whose new properties hold promise for the treatment of other diseases." At least one company in the U.S., Cooper Biomedical, is also developing alpha-1-antitrypsin. Transgene began clinicals in 1984 for use in emphysema of genetic origin and in 1985 obtained an orphan designation for alpha-1-antitrypsin use as supplementation therapy for deficient members of the ZZ phenotype population. In the area of vaccine research, Transgene noted that it has adapted a "technique of transformation of viruses by genetic engineering" to obtain a new type of vaccine. The company's first vaccine, a rabies vaccine, is being developed by Merieux Institute. Transgene said it is also applying its technology to development of an AIDS vaccine under contract from Pasteur Vaccins and in collaboration with the Pasteur Institute. The company's other research programs include development of hirudin, an "anticoagulant agent secreted by leeches that Transgene has identified for use in treating thrombosis." Transgene said it has developed a production system using microorganisms "that makes applications of hirudin feasible for the first time in therapy and diagnosis."

You may also be interested in...

Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth




Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts