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Executive Summary

ANTINAUSEANT WORLDWIDE MARKET VOLUME WILL REACH $182 MIL. IN 1990, according to an estimate by SRI International in a consulting report which projects market sizes for cancer products in the U.S., Western Europe and Japan between 1980 and 1995. According to SRI calculations, antinauseants have grown at an average annual rate of 14% between 1980 and 1985. With an estimated market size of $90 mil. for 1985 and a projected average annual growth rate of 15% for the 1985-1990 period, the antinauseant class should be one of the fastest growing cancer product markets, SRI predicted. SRI suggests that a strategy that extends beyond primary therapies and into supportive and preventative care "may present opportunities for expanded penetration of the [cancer] business." The SRl report also identifies two "secondary opportunities" -- - the possibility for improving existing products -- - which relate to antinauseants: "Long-acting multiple site antinauseants [which] are used to fight the nausea and vomiting associated with chemotherapy through pharmacologic activity at multiple sites (e.g., brain, gut) within the body"; and "transdermal antinauseant delivery systems [which] are conceptually similar to transdermal analgesic systems, but deliver antinauseants over prolonged periods during lengthy courses of chemotherapy or irradiation." The report notes that "advances in supportive care (e.g., anti-infectives, antinauseants) are occurring on broad fronts, and appear likely to improve cancer treatment, toleration to therapies, and perhaps assist in improving overall survival rates. Improvements in supportive care will also enable cancer therapy to become more aggressive and thus enable it to be used in more situations than is currently possible. The SRI report is entitled Dynamics and Opportunities in Cancer Management, A similarly titled report, Dynamics and Opportunioties in Cardiovascular Medicine, Phase 2 Europe extends SRl's study of cardiovascular disease management to the principal Western European markets. Each report -- - originally prepared for a small group of SRI clients -- - is available for $15,000 from SRI International, 333 Ravenswood Ave., Melo Park, California, 94025-3493.

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