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EMA Restricts Rubraca’s Use Due To Concerns Over Benefit & Safety

Clovis Voluntarily Dropped Drug’s Third-Line Ovarian Cancer Indication In US

 
• By Vibha Sharma

EU doctors are being told not to prescribe Rubraca as third-line treatment for cancers of the ovary, fallopian tubes or peritoneum with a BRCA mutation.

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Rubraca was not as effective as chemotherapy at prolonging patients’ lives • Source: Shutterstock

The European Medicines Agency has recommended that Clovis Oncology’s PARP inhibitor Rubraca (rucaparib) should no longer be used as a third-line treatment for BRCA-mutated ovarian, fallopian tube or primary peritoneal cancer.

A study that was designed to confirm the benefit of Rubraca for this indication failed to do so, and showed...

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