COVID-19 Vaccines: Declining Antibody Levels, Breakthrough Infections Could Spur Booster Recommendations

Although data to support use of booster doses currently are lacking, members of the US CDC's Advisory Committee on Immunization Practices suggest potential triggers for recommending revaccination after the primary series.

Booster rockets
CDC's ACIP is considering the data needed to recommend booster shots of COVID-19 vaccines. • Source: Alamy

Significant declines in antibody levels or concerning numbers of breakthrough infections in vaccinated individuals should spur consideration for booster doses of currently authorized COVID-19 vaccines, members of the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices said.

At a 23 June meeting, ACIP was asked what data would be needed to move forward with booster recommendations, and whether the risk of disease is enough to warrant a...

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