US FDA’s Project Orbis Could Streamline Global Clinical Trials In Cancer

Richard Pazdur tells the Pink Sheet that program for concurrent submission of oncology applications and collaborative review by global regulators also could speed approval in smaller countries; first applications under Project Orbis were for use of Lenvima/Keytruda combination for endometrial cancer in US, Canada, and Australia.

FDA's Project Orbis
Project Orbis provides a framework for concurrent submission and review of oncology drugs by FDA and foreign regulators. • Source: US FDA

The US Food and Drug Administration has started conducting collaborative reviews with foreign regulators under a new initiative that could help streamline global clinical trials while also speeding the approval of supplemental indications for cancer drugs in smaller countries.

On 17 September, the FDA’s Oncology Center of Excellence (OCE) announced the launch of Project Orbis, a collaboration that provides a framework for concurrent submission and review of

Lenvima/Keytruda Combo Indication In US

Treatment of patients with advanced endometrial carcinoma that is not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), and who have disease progression following prior

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