Decompensated Cirrhosis May Be Another HCV Edge For Gilead; Bristol, J&J Still In Contention

Bristol and Johnson & Johnson have not abandoned their efforts to take a relevant place in the HCV market, although J&J isn't expected to produce triple combination data until next year.

Although great focus at the just-completed American Association for the Study of Liver Diseases conference was placed on treatment of genotype 3 infections in hepatitis C, the most difficult HCV subpopulation to cure is patients in any genotype who have decompensated cirrhosis. A recent labeling change for AbbVie Inc.'s HCV combination therapies may make this one more treatment niche where Gilead Sciences Inc. will enjoy a competitive edge.

Following an FDA safety alert Oct. 22 about liver failure and deaths in patients taking AbbVie's two HCV drugs –...

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