Does Bristol Nuc’s Possible Cardiac Toxicity Portend A Class Effect?
Executive Summary
Bristol-Myers Squibb has halted study of its Phase II nucleoside polymerase inhibitor for hepatitis C due to one trial patient suffering heart failure. It remains unclear if that event is related to the study drug, but do repeated toxicity issues with “nucs” indicate a class effect?
You may also be interested in...
With FDA Hold Continuing, Idenix To Focus On NS5A Inhibitor And New Uridine Nucleosides
HCV-focused biotech tells J.P. Morgan conference audience it is making IDX719, its Phase II NS5A inhibitor, its lead program and hopes to start a non-exclusive combination trial with another company’s protease inhibitor this year.
Gilead Already Seeking Stribild Successor, Going Solo On Key HCV Combo
Just weeks after the apparently successful launch of its HIV “quad pill,” Gilead already is talking up a new compound with potential as part of an HIV combination therapy. And in HCV, the company is preparing a new study without partner Bristol-Myers Squibb.
Cruel Summer: High-Profile Trial Failures Dominate R&D News Flow
As the summer of 2012 wears on, an outpouring of negative clinical trial news for high-profile new drug candidates has made the season more a time of doldrums than of fun in the sun for big pharma.