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Forest Files Memantine/Donepezil Fixed Combination For Alzheimer’s

 
• By Shirley Haley

Commercialization of the fixed-dose combo buys lifecycle management for Forest and should support future drug development for partner Adamas, the originator of the technology behind the combination.

For Forest Laboratories Inc., the fixed-dose combination of memantine and donepezil for Alzheimer’s disease will extend the life of its lucrative Namenda franchise, while royalty payments that start five years post-launch would support development of other projects in originator Adamas Pharmaceuticals Inc.’s CNS pipeline.

On March 4, Forest announced the NDA submission for the fixed-dose combination of extended-release memantine and immediate-release donepezil, two drugs that have been marketed separately but used together for years...

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