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Glaxo’s Emerging BRAF/MEK Melanoma Combo Threatens Roche’s Zelboraf

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Phase I/II data for Glaxo’s BRAF/MEK combination of dabrafenib and trametinib, both pending FDA approval as single agents, suggest compelling efficacy. The combination may see off-label use if the drugs are approved as monotherapies, though payment could be a big hurdle.

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