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Canada on omeprazole

This article was originally published in The Tan Sheet

Executive Summary

Long-term use of Nexium does not increase the risk of cardiovascular events, Health Canada announces Feb. 27. Additionally, the agency says it is unable to conclude definitively whether long-term use of Losec (omeprazole) increases cardiovascular risk, and will continue to evaluate it if more data emerge. The agency recommends patients taking either drug not change their medication unless directed by their doctor, "as ulcers and reflux can lead to other complications if left untreated." FDA conducted its own safety review of the products in August after study results raised questions about long-term use of the drugs and cardiovascular outcomes. However, the agency concluded the data did not indicate the presence of a true effect (1"The Tan Sheet" Dec. 17, 2007, In Brief)...

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