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CRN risk assessments

This article was originally published in The Tan Sheet

Executive Summary

The Council for Responsible Nutrition has developed risk assessments for Coenzyme Q10, carotenoids lutein and lycopene, and creatine monohydrate that will be published in the journal Regulatory Toxicology & Pharmacology. The assessments aim to provide regulators with a science-based guideline determining safe upper levels for the nutrients when used in dietary supplements. "Coenzyme Q10, lutein, lycopene and creatine are becoming more popular and more prevalent in dietary supplements, and a safe upper level have not as of yet been established by governing bodies for these nutrients," according to Andrew Shao, PhD, CRN VP-Scientific & Regulatory Affairs. Shao and CRN VP-Scientific & International Affairs John Hathcock, PhD, reviewed randomized, controlled, human clinical trials to determine the safe upper levels. They arrived at daily ULS values of 1200 mg for CoQ10, 20 mg for lutein, 75 mg for lycopene, and 5 g for creatine. CRN will next conduct risk assessments for carnitine, glucosamine, and chondroitin sulfate...
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