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NSAIDs and heart failure

This article was originally published in The Tan Sheet

Executive Summary

NSAIDs users had a 30% increased risk of first hospital admission for heart failure (HF) compared to the general population in a study published recently in the British journal Heart. The nested case-control study included 228,660 patients in a cohort from the general UK population between the ages of 60 and 84 who were enrolled with a general practitioner for at least two years and had one year since their first computerized prescription, Consuelo Huerta, Centro Español de Investigació Farmacoepidemiológica, Madrid, Spain, et al., explain. The study results are consistent with previous research that suggests NSAIDs worsen symptoms of heart failure that results in hospitalization among high-risk patients, "but also that NSAIDs trigger the risk of HF hospitalization in patients without a history of clinical HF," the authors state. One of the studies weaknesses includes an absence of information on OTC drug use, although the study accurately captured Rx NSAID use through the UK computerized prescription database, Huerta et al. state...

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