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NSAID Use Long-Term May Increase Cardiovascular Death Risk – Study

This article was originally published in The Tan Sheet

Executive Summary

A small study showing that smokers using NSAIDs are twice as likely to die from cardiovascular causes as smokers who do not use NSAIDs represents another blow to the safety profile of the drug class

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Lancet study a sham?

Editors of The Lancet issued an "expression of concern" Jan. 17 about a study published in the journal in October which appeared to be based on "complete fabrication" by the study's lead author. John Sudbo, MD, PhD, Norwegian Radium Hospital, et al., found in a study that long-term use of NSAIDs was linked to reduced incidence of oral cancer but increased risk of death from cardiovascular disease. The hospital alerted Lancet editors to the problem Jan. 13, and the publication states that "the journal has not yet received written confirmation...that fabrication actually took place." The hospital has appointed an investigation committee to look into the matter. Sudbo's findings were first presented at the American Association for Cancer Research annual meeting in April (1"The Tan Sheet" April 25, 2005, p. 10)...

Lancet study a sham?

Editors of The Lancet issued an "expression of concern" Jan. 17 about a study published in the journal in October which appeared to be based on "complete fabrication" by the study's lead author. John Sudbo, MD, PhD, Norwegian Radium Hospital, et al., found in a study that long-term use of NSAIDs was linked to reduced incidence of oral cancer but increased risk of death from cardiovascular disease. The hospital alerted Lancet editors to the problem Jan. 13, and the publication states that "the journal has not yet received written confirmation...that fabrication actually took place." The hospital has appointed an investigation committee to look into the matter. Sudbo's findings were first presented at the American Association for Cancer Research annual meeting in April (1"The Tan Sheet" April 25, 2005, p. 10)...

Lancet study a sham?

Editors of The Lancet issued an "expression of concern" Jan. 17 about a study published in the journal in October which appeared to be based on "complete fabrication" by the study's lead author. John Sudbo, MD, PhD, Norwegian Radium Hospital, et al., found in a study that long-term use of NSAIDs was linked to reduced incidence of oral cancer but increased risk of death from cardiovascular disease. The hospital alerted Lancet editors to the problem Jan. 13, and the publication states that "the journal has not yet received written confirmation...that fabrication actually took place." The hospital has appointed an investigation committee to look into the matter. Sudbo's findings were first presented at the American Association for Cancer Research annual meeting in April (1"The Tan Sheet" April 25, 2005, p. 10)...

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