Chinese botanicals & hepatotoxicity
This article was originally published in The Tan Sheet
Executive Summary
Synthetic chemical N-nitroso-fenfluramine may be responsible for poisoning livers of 12 patients in Japan who took Chaso or Onshido botanical supplements, Masayuki Adachi, MD, Keio University, Tokyo, et al. report in September Annals of Internal Medicine. Record review of 12 patients revealed symptoms including fatigue, appetite loss that appeared five to 40 days after ingestion. One patient died, while another received a liver transplant, Adachi et al. state. The other 10 patients' conditions improved. "Severity of hepatotoxicity does not seem to correlate with duration of use or the amount of product ingested," the researchers note. Adachi and colleagues suggest further toxicologic analysis of the Chinese botanicals...
You may also be interested in...
Japan Grants Global-First Approval To Zolbetuximab, 15 Other New Drugs
Astellas's first-in class CLDN18.2-targeting antibody receives its first approval worldwide, while crovalimab and a number of drugs for rare diseases also receive nods from regulators and are now awaiting reimbursement price-listing.
Hanmi-OCI Merger Hits Wall As Brothers Win Shareholder Vote, Board Seats
The planned merger of Korea's Hanmi Pharm Group with OCI Group hits a major speed bump as the two sons of Hanmi's founder and other candidates recommended by them secture board seats. But it remains to be seen how the Lim brothers will fulfil their ambitious promises.
Beauty Firms Using AI-Based Tools Could Be Subject To Health Privacy Laws In US States
Using AI-based programs to collect and store consumer information risks running afoul of new health privacy laws cropping up in US states. Lack of federal regulation or guidance on the issue is one of the biggest challenges for beauty firms deploying AI, according to Stacy Marcus, partner at Reed Smith LLP.