Acetaminophen research
This article was originally published in The Tan Sheet
Executive Summary
High doses of analgesic clear "rapidly and completely" from the bloodstream, researchers state at Society of Toxicology annual meeting in Salt Lake City. "Analysis of plasma acetaminophen levels showed that doses as high as 8 g/day, or twice the maximum daily recommended dose, did not accumulate and the drug was consistently cleared from the bloodstream," according to McNeil's Cathy Gelotte, PhD. Double-blind, placebo-controlled study divided 36 participants into three groups with dosing regimens of 4 g/d, 6 g/d or 8 g/d for three days. Participants underwent blood sampling during the first and last dose of each daily regimen, Gelotte reports. NDAC members recently advised acetaminophen labeling changes to clarify potential for liver toxicity (1"The Tan Sheet" Sept. 23, 2002, p. 4)...
You may also be interested in...
Acetaminophen “Black Box” Warning Would “Scare” Users, NDAC Rep Says
Use of a "black box" warning on OTC acetaminophen labeling would be an inappropriate means for alerting consumers about potential liver damage, two consultants to FDA's Nonprescription Drugs Advisory Committee said Sept. 19
‘Clear’ Is In The Eye Of The Beholder, New York, CRN Argue In Age-Restricted Sales Litigation
CRN’s request for clarification, as it continues litigating complaint in US District Court for Southern New York, highlights what it contends is vague and overly general language in the legislation passed in October with a 22 April effective date.
Biogen Sees Improving Momentum In Slow Leqembi Launch
Sales of the company’s new drugs have a lot of growing to do to make up for older products’ declines, but Biogen highlighted signs of strength for new launches in its Q1 report.