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Acetaminophen research

This article was originally published in The Tan Sheet

Executive Summary

High doses of analgesic clear "rapidly and completely" from the bloodstream, researchers state at Society of Toxicology annual meeting in Salt Lake City. "Analysis of plasma acetaminophen levels showed that doses as high as 8 g/day, or twice the maximum daily recommended dose, did not accumulate and the drug was consistently cleared from the bloodstream," according to McNeil's Cathy Gelotte, PhD. Double-blind, placebo-controlled study divided 36 participants into three groups with dosing regimens of 4 g/d, 6 g/d or 8 g/d for three days. Participants underwent blood sampling during the first and last dose of each daily regimen, Gelotte reports. NDAC members recently advised acetaminophen labeling changes to clarify potential for liver toxicity (1"The Tan Sheet" Sept. 23, 2002, p. 4)...
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