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Propylene Glycol Toxicity Subject Of February NTP Meeting

This article was originally published in The Tan Sheet

Executive Summary

Consumers would have to ingest more than 15 g/kg of propylene glycol to experience a lethal effect, a National Toxicology Program Center for the Evaluation of Risks to Human Reproduction draft report estimates

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Patients who suffer from allergic contact dermatitis due to treatment with topical minoxidil solution "should be advised to undergo patch testing to determine the causative allergen," researchers report in February Journal of the American Academy of Dermatology. Edward Friedman, et al., NYU School of Medicine, suggest patients could be sensitive to an agent in the solution other than minoxidil, such as propylene glycol, in which case "they should be given the option of formulations compounded with alternative solvents." Friedman et al. patch-tested 11 individuals with alopecia; nine showed a positive allergic reaction to propylene glycol, while only four reacted to minoxidil...

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