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N-9 efficacy study

This article was originally published in The Tan Sheet

Executive Summary

Risk of HIV-1 infection was "especially high" in women who used nonoxynol-9 more than 3.5 times per day due to "an increasing frequency of lesions" caused by the spermicide, researchers report in Sept. 28 Lancet. Lut Van Damme, MD, Institute of Tropical Medicine, Antwerp, Belgium, et al., found that at low-frequency use, N-9 had no effect on HIV-1 infection. Researchers randomized 892 sex workers in South Africa, Thailand, Benin and Ivory Coast to either 3.5% N-9 gel or placebo; investigators conclude the drug "no longer has a part to play in HIV-1 prevention"...





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