Milk thistle & HIV
This article was originally published in The Tan Sheet
Executive Summary
"Milk thistle in commonly administered dosages should not interfere with indinavir therapy in patients infected with" HIV, researchers report in May Pharmacotherapy. Stephen Piscitelli, et al., National Institutes of Health, conducted prospective open-label study of 10 healthy volunteers and found an insignificant 9% reduction in presence of HIV drug indinavir after three weeks of dosing with milk thistle. Participants received four doses of indinavir 800 mg at baseline, then took 175 mg milk thistle (containing 153 mg silymarin) three times/day for three weeks. In similar research, Piscitelli et al. had shown HIV drug interactions with garlic, St. John's wort (1"The Tan Sheet" Dec. 10, 2001, p. 11)...
You may also be interested in...
Garlic Supplements, Protease Inhibitor Interactions Troublesome – NIH Study
A National Institutes of Health study finding garlic supplements reduce plasma concentration levels of an HIV protease inhibitor by approximately 50% could spur drug interaction warnings on such supplements
Dr Reddy’s Knocked Back On Rituximab In US
Dr Reddy’s has received a complete response letter from the US FDA, knocking back its proposed rituximab biosimilar rival to Rituxan.
Sandoz And Samsung Celebrate Stelara Rival’s EU Approval
Sandoz and Samsung Bioepis have received final European Commission approval for their partnered Pyzchiva biosimilar rival to Stelara. But with European competition on ustekinumab due to kick off in just a matter of months, further applicants are also waiting in the wings.