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This article was originally published in The Tan Sheet

Executive Summary

Fluidized bed processing deemed "feasible method" for granulating low levels of hydrophobic, hydrophilic active ingredients in tablets, Abbott Labs researchers report at AAPS. Actives were suspended or dissolved in water, then sprayed during fluidization on excipients sugar or starch. Sugar processing yielded 93%, 97% of expected potency for hydrophilic, hydrophobic actives, respectively, while potency results for use of starch were 93%, 78%
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