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Softgel colorants

This article was originally published in The Tan Sheet

Executive Summary

Carmine has no adverse effects on gelatin and is a suitable colorant for softgels, while carob powder should be avoided due to observed disintegration of gelatin, Banner Pharmacaps' Aristippos Gennadios says in AAPS abstract. Gennadios produced vitamin E and selenium softgels, colored them with either carmine/titanium dioxide or carob powder/ titanium dioxide and stored them for three months. Softgels then were tested for disintegration in acetate buffer (pH 4.5). Carmine-colored softgels disintegrated in 4.5-7.5 minutes, while carob softgels did not disintegrate after 45 minutes, suggesting carob powder "cross-linked" gelatin during storage
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