Executive Summary

St. John's wort constituent has "clinically significant effect on mild to moderately depressed nondysthymic patients," researchers at Frederiksberg Hospital, Denmark, conclude, cautioning "measures of depression are subject to large placebo effects requiring large groups of patients for comparative studies." In the study, 150 patients were randomized to receive placebo or 2,350 mg/day hypericum and were followed up at three and six weeks, C. Randlov and colleagues explain. The supplement was well tolerated and produced no serious adverse events, Randlov adds