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Vitamin E and CVD

This article was originally published in The Tan Sheet

Executive Summary

Natural source vitamin E (400 IU/day) has neutral effect on arterial plaque and other heart disease risk factors, subset study of Heart Outcomes Prevention Evaluation finds. "There were no differences in atherosclerosis progression rates between patients on vitamin E and those on placebo," SECURE study researchers Eva Lonn, MD, McMaster University, Hamilton, Ontario, et al. say in Feb. 20 issue of Circulation. The 732-patient Study to Evaluate Carotid Ultrasound Changes in Patients Treated with Ramipril and Vitamin E was part of the HOPE trial, which found similar results regarding the nutrient (1"The Tan Sheet" Jan. 24, 2000, p. 11)

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Long-term daily vitamin E supplementation has no apparent effect on cardiovascular outcomes in high-risk individuals 55 years and older, Heart Outcomes Prevention Evaluation Study (HOPE) investigators report in the Jan. 20 New England Journal of Medicine.

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