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Aspirin inhibition

This article was originally published in The Tan Sheet

Executive Summary

Taking ibuprofen before aspirin may block the latter's cardioprotective benefits, University of Pennsylvania researchers report at the American College of Rheumatology annual meeting in Philadelphia Nov. 1. Eighteen subjects were split into three groups and received 81 mg aspirin two hours before taking either 400 mg ibuprofen, 1,000 mg acetaminophen or 25 mg rofecoxib. After six days, subjects underwent a two-week washout period and then switched the medications' order. Taking ibuprofen prior to aspirin antagonized "the irreversible platelet inhibition induced by aspirin," researchers say, noting other medications did not have a similar effect. The study was supported by Bayer

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