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Melatonin and sleep

This article was originally published in The Tan Sheet

Executive Summary

Six of seven sightless participants in a crossover study experienced entrainment of "free-running" circadian rhythms after receiving 10 mg of botanical for three to nine weeks, Robert Sack, MD, et. al., Oregon Health Science University, report in the Oct. 12 New England Journal of Medicine. Subjects were given melatonin - and later placebo - an hour before their preferred bedtime each night. Timing of the melatonin administration was based on the melatonin phase-response curve. Researchers recommend starting treatment "on a day when the plasma melatonin is predicted to rise above 10 [picograms] per milliliter a few hours before the time the drug would be administered"
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