Ketoprofen/acetaminophen GI effects
This article was originally published in The Tan Sheet
Executive Summary
Seven-day study involving 24 healthy subjects finds "even at lower (OTC) doses (75 mg/day) ketoprofen is associated with significant gastrointestinal irritation," researchers from Houston Institute of Clinical Research and McNeil Consumer Products (Tylenol) report. Published in the July American Journal of Gastroenterology, the randomized, double-blind, three-way crossover study compared ketoprofen with acetaminophen 4,000 mg/day. "The acetaminophen group showed no difference from placebo," while two subjects on ketoprofen developed "frank gastric ulcers," Frank Lanza, MD, et al. note. The Aspirin Foundation of America said the study is "obviously biased and...dangerously misleading." Bayer (Actron) and Whitehall-Robins (Orudis KT) sell OTC ketoprofen products...
You may also be interested in...
Supplement GMP Warning Letters Make Modest Debut In 2010
Finalization of a settlement between the Federal Trade Commission and Rexall Sundown regarding unsupported cellulite treatment claims for the firm's Cellasene dietary supplement hinges upon approval of two related class action settlements pending in California and Florida, according to FTC
In Brief
Combe sells most of its OTC brands
People In Brief
Perrigo promotes in pricing, planning