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COX-2 inhibitor arthritis testing should include low-dose aspirin users, advisory cmte. says.

This article was originally published in The Tan Sheet

Executive Summary

COX-2 Rx ARTHRITIS AGENT TESTING SHOULD INCLUDE LOW-DOSE ASPIRIN USERS as a special subpopulation, FDA's Arthritis Advisory Committee agreed at a meeting on COX-2 inhibitor safety issues held in Gaithersburg, Md. March 24. Committee member David Yocum, MD, University of Arizona, said he is "concerned about combination therapies" after hearing data that regular low-dose aspirin use leads to a higher risk of gastrointestinal complications. COX-2 inhibitors also are suspected of causing GI problems. Believed to be the next generation of arthritis drugs, COX-2 agents act as anti-inflammatories through their selective inhibition of the cyclooxygenase-2 protein. Searle, Merck and Boehringer Ingelheim are developing COX-2 products for Rx sale.
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