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Dextromethorphan linked to craniofacial defects in chick embryos in U. Nebraska study.

This article was originally published in The Tan Sheet

Executive Summary

DEXTROMETHORPHAN LINKED TO BIRTH DEFECTS IN CHICK EMBRYOS, researchers from the University of Nebraska Medical Center conclude in a report published in the January issue of Pediatric Research. Thomas Rosenquist, PhD, et al., say the nonprescription cough suppressant dextromethorphan "is shown by the present data using this model to be a powerful inducer of both congenital defects and embryonic death when present in micromolar concentrations." The researchers note that similarities in early embryonic development permit data derived from experiments with early avian embryos to "perhaps be applied broadly for other species when they are exposed to the same teratogens, including the early human embryo."
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