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Low-dose aspirin should be used in colorectal cancer prevention studies, researchers say.

This article was originally published in The Tan Sheet

Executive Summary

LOW-DOSE ASPIRIN FOR COLORECTAL CANCER STUDIES SUGGESTED based on the results of a 66-patient, 14-day study measuring the effect of aspirin at 40.5 mg, 81 mg, 162 mg, 324 mg and 648 mg daily on prostaglandins E2 and F2alpha. The short-term study by Mack Ruffin et al., University of Michigan, published in the Aug. 6 Journal of the National Cancer Institute, was conducted to determine the lowest dose of aspirin that could significantly reduce the level of colorectal prostaglandins as a baseline for future studies seeking to find new chemopreventive agents for colorectal cancers. High levels of prostaglandins have been found in colon cancer tissues.

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