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Aspirin/warfarin no more effective than aspirin alone in preventing second MI -- Lancet.

This article was originally published in The Tan Sheet

Executive Summary

ASPIRIN/WARFARIN COMBO NOT RECOMMENDED FOR SECOND MI PREVENTION because it is no more effective than aspirin alone, Coumadin Aspirin Reinfarction Study (CARS) investigators conclude in a study published in the Aug. 9 Lancet. "Low, fixed-dose warfarin (1 mg or 3 mg) combined with low-dose aspirin (80 mg) in patients who have had myocardial infarction does not provide clinical benefit beyond that achievable with 160 mg aspirin monotherapy," the CARS group states. Valentin Fuster, MD/PhD, Mount Sinai Hospital, New York City, chaired the CARS writing and steering committee, which oversaw the design and conduct of the randomized, double-blind trial. The study was funded by Du Pont Merck Pharmaceutical.

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