Fluoride bioavailability in toothpastes: alternative test method proposed by Tom's of Maine.
This article was originally published in The Tan Sheet
ANTICARIES FLUORIDE BIOAVAILABILITY ALTERNATIVE TESTING PROCEDURE PROPOSED by Tom's of Maine to meet biological test requirements for fluoride dentifrice drug products in the OTC anticaries final monograph. In a Feb. 16 citizen petition, the natural toothpaste marketer asked that FDA accept data from an "intra-oral remineralization test in human subjects" as a replacement for the animal caries reduction test specified in the monograph.
You may also be interested in...
Tom's of Maine intends to market new dentifrice products formulated with sodium monofluoro-phosphate in a calcium-only abrasive system pending reference standard testing for fluoride bioavailability, according to the Kennebunk, Maine company
Perrigo promotes in pricing, planning