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Folate test methods

This article was originally published in The Tan Sheet

Executive Summary

Federation of American Societies for Experimental Biology final report on discrepancies in the testing methodology used to determine serum and red blood cell folate levels in Phase I of the third Health and Nutrition Examination Survey (NHANES III) is expected in September. FASEB's tentative report found serum and folate values derived from radioassay kits to be "about 30% higher" than expected due to a difference in calibration standards used at the time the kits were introduced in 1975. At a July 15 public meeting, Jacob Selhub, PhD, USDA Human Nutrition Research Center, stressed the "need to develop a different methodology that is more direct than both the microbial and radioassay tests"
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