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LIDOCAINE METABOLITE 2,6-XYLIDINE FOUND IN HUMAN LIVER SLICES

This article was originally published in The Tan Sheet

Executive Summary

LIDOCAINE METABOLITE 2,6-XYLIDINE FOUND IN HUMAN LIVER SLICES, according to preliminary study results reported at a June 10 meeting of FDA's Anesthetic and Life Support Drugs Advisory Committee. "The important finding is that xylidine itself is produced by human liver slices," FDA Division of Clinical Pharmacology Branch Chief John Strong, PhD, asserted at the meeting. While researchers have "known for years" that lidocaine is broken down by the liver through a number of steps, Strong said, it was not known whether 2,6-xylidine was one of the intermediate compounds produced in that process.
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