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Burroughs Wellcome Zovirax

This article was originally published in The Tan Sheet

Executive Summary

Article in May issue of Archives of Dermatology reports on long-term trial in over 400 patients with recurring genital herpes treated with oral acylovir 400 mg b.i.d. for more than five years. More than 20% of the patients receiving suppressive therapy have been recurrence free during the entire study, Leonard Goldberg, MD, Baylor College of Medicine, et al., reported. In addition, the study found that the "majority of patients were recurrence free on an annual basis during suppressive therapy" and and that therapy "was well-tolerated" and "not associated with serious side effects or cumulative toxicity." Burroughs Wellcome expects to file a supplemental NDA for an Rx-to-OTC switch of oral Zovirax for the prevention of genital herpes outbreaks this summer ("The Tan Sheet" May 10, In Brief).

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