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Laguna Coalesces Around Effort To Treat A-Fib With A Pill Rather Than Electric Shock

This article was originally published in The Pink Sheet Daily

Executive Summary

An oral drug that could replace direct current cardioversion as the standard for restoring normal sinus rhythm in atrial fibrillation patients could be both more patient-friendly and a cost-saver for the health care system.

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Like many a start-up before it, ChanRx Corp. aims to repurpose a compound discovered by others for a new use. Unlike most repurposing efforts, however, this compound, called vanoxerine, has never actually been approved as a drug. Although it has thrice been taken into Phase I trials that yielded acceptable safety data, the compound showed no efficacy for treatment of Parkinson’s disease, depression or cocaine addiction. Noting that vanoxerine could influence muscle that beats rapidly, the start-up is developing it as an oral treatment for atrial fibrillation.

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