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Avila/Clovis Partnership Moves To The Clinic

This article was originally published in The Pink Sheet Daily

Executive Summary

Avila and Clovis have selected a drug candidate to move into human testing.

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Sanofi Bulks Up Oncology Development With Avila Collaboration

Sanofi-Aventis adds to its expertise in oncology by striking a deal with Massachusetts-based Avila Therapeutics for the biotech's covalent-bonding technology in a deal that could be worth up to $800 million.

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As much as anti-hepatitis C drug telaprevir is leading the way, it has also defined what is going to be needed in a best-in-class molecule, according to the founders of Avila Therapeutics Inc. Avila's platform technology creates highly selective drugs that bond covalently to receptors, effectively silencing them and overcoming resistance mechanisms for the day or two the targets live. The Waltham, MA, biotech is the only company currently focused on covalent drugs, the company believes.

Clovis And Avila Join In Oncology Drug/Diagnostic Deal

One year after securing startup financing, Clovis has acquired rights to a second program, this time Avila's EGFR mutant-selective inhibitor program.

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