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Pfizer Finds Backup For Aricept In Medivation’s Dimebon

This article was originally published in The Pink Sheet Daily

Executive Summary

Medivation Alzheimer’s candidate is unique for its disease-modifying potential.

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Deals Of The Week: Genentech/Constellation, Bayer/Ventana, Genzyme/Veracyte

Epigenetics took the spotlight this week, with Genentech being the latest pharma to move into the field in partnership with Constellation Pharmaceuticals. In other deals, Bayer signed Ventana to develop a companion diagnostic, and Pfizer walked away from Medivation and Alzheimer’s drug Dimebon.

Pfizer/Medivation End Dimebon Development Following Another Failed Alzheimer’s Trial

A second failed efficacy trial, CONCERT, provided the final nail in the coffin for the once-promising treatment for Alzheimer’s disease, serving as a cautionary tale against excessive enthusiasm for early clinical trial results.

Almost All Hopes Dashed For Pfizer/Medivation's Dimebon

After a disastrous failure in Alzheimer's disease last year, Dimebon once again disappoints in a Phase III trial - this time in Huntington disease.

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